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Daunorubicin hydrochloride

CAS No. 23541-50-6

Daunorubicin hydrochloride ( RP 13057 Hydrochloride;Daunomycin;RP13057 Hydrochloride )

Catalog No. M13676 CAS No. 23541-50-6

Daunorubicin is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 28 In Stock
10MG 46 In Stock
25MG 76 In Stock
50MG 110 In Stock
100MG 177 In Stock
200MG 282 In Stock
500MG 443 In Stock
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Biological Information

  • Product Name
    Daunorubicin hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Daunorubicin is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells.
  • Description
    Daunorubicin is potent topoisomerase II (Topo II) inhibitor, interacts with DNA by intercalation and inhibition of macromolecular biosynthesis in cancer cells; Daunorubicin is a chemotherapy agent used to treat multiple cancer, secifically used for acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and Kaposi's sarcoma; Daunorubicin and it's derivatives are widely used as payloads in antibody-drug conjugates (ADCs).Chemotherapeutic Agents Approved
  • Synonyms
    RP 13057 Hydrochloride;Daunomycin;RP13057 Hydrochloride
  • Pathway
    Antibody Drug Conjugates (ADC)
  • Target
    ADC Cytotoxin
  • Recptor
    DNAsynthesis
  • Research Area
    Cancer
  • Indication
    Chemotherapeutic

Chemical Information

  • CAS Number
    23541-50-6
  • Formula Weight
    563.98
  • Molecular Formula
    C27H30ClNO10
  • Purity
    >98% (HPLC)
  • Solubility
    H2O: ≥ 34 mg/mL
  • SMILES
    C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl
  • Chemical Name
    5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride (1:1), (8S,10S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Latif ZA, et al. Cancer. 1980 Mar 15;45(6):1326-33.
2. Hurwitz E, et al. Int J Cancer. 1979 Oct 15;24(4):461-70.
3. Aboud-Pirak E, et al. Proc Natl Acad Sci U S A. 1989 May;86(10):3778-81.
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